Cytotoxicity of copper and cobalt complexes of furfural semicarbazone and thiosemicarbazone derivatives in murine and human tumor cell lines
Identifieur interne : 000310 ( France/Analysis ); précédent : 000309; suivant : 000311Cytotoxicity of copper and cobalt complexes of furfural semicarbazone and thiosemicarbazone derivatives in murine and human tumor cell lines
Auteurs : I. H. Hall [États-Unis] ; C. B. Lackey [États-Unis] ; T. D. Kistler [États-Unis] ; R. W. Jr Durham [États-Unis] ; E. M. Jouad [France] ; M. Khan [France] ; X. D. Thanh [France] ; S. Djebbar-Sid [France] ; O. Benali-Baitich [Algérie] ; G. M. Bouet [France]Source :
- Pharmazie [ 0031-7144 ] ; 2000.
Descripteurs français
- Pascal (Inist)
- Activité biologique, Anticancéreux, Cytotoxicité, In vitro, Lignée cellulaire, Cellule tumorale, Homme, Animal, Souris, Lignée L1210, Inhibition, Synthèse DNA, Synthèse chimique, Cuivre Complexe, Cobalt Complexe, Complexe chloro, Complexe bromo, Complexe aqua, Coordinat organique, Semicarbazone, Thiosemicarbazone, Hétérocycle oxygène, Cycle 5 chaînons, Furane dérivé, Furfural(5-méthyl) semicarbazone, Furfural thiosemicarbazone.
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Animal, Antineoplastic agent, Aqua complex, Biological activity, Bromo complex, Cell line, Chemical synthesis, Chloro complex, Cobalt Complexes, Copper Complexes, Cytotoxicity, DNA synthesis, Five membered ring, Furan derivatives, Human, In vitro, Inhibition, L1210 cell line, Mouse, Organic ligand, Oxygen heterocycle, Semicarbazones, Thiosemicarbazone, Tumor cell.
Abstract
The 2-furfural semicarbazone and thiosemicarbazone copper and cobalt complexes demonstrated potent cytotoxicity against the growth of suspended leukemias and lymphomas as well as human lung MB9812, colon SW480, ovary 1-A9 and HeLa-S3 uterine carcinoma. In L1210 lymphoid leukemia cell the complexes inhibited preferentially DNA synthesis over 60 min at 25 to 100 μM. The copper and cobalt complexes functioned by multiple mechanisms to suppress synthetic steps in nucleic acid metabolism to reduce deoxynucleotide pools for incorporation into DNA. At high concentrations the complexes suppressed human DNA topoisomerase II activity with DNA nicks and DNA fragmentation but they did not alkylate the bases of DNA, cause intercalation between base pairs or cause cross-linking of DNA strands.
Affiliations:
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Pascal:01-0086221Le document en format XML
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H." last="Hall">I. H. Hall</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Medicinal Chemistry & Natural Products, School of Pharmacy, University of North Carolina</s1><s2>Chapel Hill</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Chapel Hill</wicri:noRegion></affiliation></author><author><name sortKey="Lackey, C B" sort="Lackey, C B" uniqKey="Lackey C" first="C. B." last="Lackey">C. B. Lackey</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Medicinal Chemistry & Natural Products, School of Pharmacy, University of North Carolina</s1><s2>Chapel Hill</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Chapel Hill</wicri:noRegion></affiliation></author><author><name sortKey="Kistler, T D" sort="Kistler, T D" uniqKey="Kistler T" first="T. D." last="Kistler">T. D. 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Jouad</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratoire de Chimie de Coordination , Faculte de Pharmacie</s1><s2>Angers</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Angers</settlement></placeName></affiliation></author><author><name sortKey="Khan, M" sort="Khan, M" uniqKey="Khan M" first="M." last="Khan">M. 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Djebbar-Sid</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratoire de Chimie de Coordination , Faculte de Pharmacie</s1><s2>Angers</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Angers</settlement></placeName></affiliation></author><author><name sortKey="Benali Baitich, O" sort="Benali Baitich, O" uniqKey="Benali Baitich O" first="O." last="Benali-Baitich">O. Benali-Baitich</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Laboratoire de Chimie de Coordination, USTHB, Institut de Chimie</s1><s2>Alger</s2><s3>DZA</s3><sZ>9 aut.</sZ></inist:fA14><country>Algérie</country><placeName><settlement type="city">Alger</settlement><region nuts="2">Wilaya d'Alger</region></placeName></affiliation></author><author><name sortKey="Bouet, G M" sort="Bouet, G M" uniqKey="Bouet G" first="G. M." last="Bouet">G. M. Bouet</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratoire de Chimie de Coordination , Faculte de Pharmacie</s1><s2>Angers</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Angers</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Pharmazie</title><title level="j" type="abbreviated">Pharmazie</title><idno type="ISSN">0031-7144</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Pharmazie</title><title level="j" type="abbreviated">Pharmazie</title><idno type="ISSN">0031-7144</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Antineoplastic agent</term><term>Aqua complex</term><term>Biological activity</term><term>Bromo complex</term><term>Cell line</term><term>Chemical synthesis</term><term>Chloro complex</term><term>Cobalt Complexes</term><term>Copper Complexes</term><term>Cytotoxicity</term><term>DNA synthesis</term><term>Five membered ring</term><term>Furan derivatives</term><term>Human</term><term>In vitro</term><term>Inhibition</term><term>L1210 cell line</term><term>Mouse</term><term>Organic ligand</term><term>Oxygen heterocycle</term><term>Semicarbazones</term><term>Thiosemicarbazone</term><term>Tumor cell</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Activité biologique</term><term>Anticancéreux</term><term>Cytotoxicité</term><term>In vitro</term><term>Lignée cellulaire</term><term>Cellule tumorale</term><term>Homme</term><term>Animal</term><term>Souris</term><term>Lignée L1210</term><term>Inhibition</term><term>Synthèse DNA</term><term>Synthèse chimique</term><term>Cuivre Complexe</term><term>Cobalt Complexe</term><term>Complexe chloro</term><term>Complexe bromo</term><term>Complexe aqua</term><term>Coordinat organique</term><term>Semicarbazone</term><term>Thiosemicarbazone</term><term>Hétérocycle oxygène</term><term>Cycle 5 chaînons</term><term>Furane dérivé</term><term>Furfural(5-méthyl) semicarbazone</term><term>Furfural thiosemicarbazone</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The 2-furfural semicarbazone and thiosemicarbazone copper and cobalt complexes demonstrated potent cytotoxicity against the growth of suspended leukemias and lymphomas as well as human lung MB9812, colon SW480, ovary 1-A9 and HeLa-S<sup>3</sup> uterine carcinoma. In L1210 lymphoid leukemia cell the complexes inhibited preferentially DNA synthesis over 60 min at 25 to 100 μM. The copper and cobalt complexes functioned by multiple mechanisms to suppress synthetic steps in nucleic acid metabolism to reduce deoxynucleotide pools for incorporation into DNA. At high concentrations the complexes suppressed human DNA topoisomerase II activity with DNA nicks and DNA fragmentation but they did not alkylate the bases of DNA, cause intercalation between base pairs or cause cross-linking of DNA strands.</div></front></TEI><affiliations><list><country><li>Algérie</li><li>France</li><li>États-Unis</li></country><region><li>Pays de la Loire</li><li>Wilaya d'Alger</li></region><settlement><li>Alger</li><li>Angers</li></settlement></list><tree><country name="États-Unis"><noRegion><name sortKey="Hall, I H" sort="Hall, I H" uniqKey="Hall I" first="I. H." last="Hall">I. H. Hall</name></noRegion><name sortKey="Durham, R W Jr" sort="Durham, R W Jr" uniqKey="Durham R" first="R. W. Jr" last="Durham">R. W. Jr Durham</name><name sortKey="Kistler, T D" sort="Kistler, T D" uniqKey="Kistler T" first="T. D." last="Kistler">T. D. Kistler</name><name sortKey="Lackey, C B" sort="Lackey, C B" uniqKey="Lackey C" first="C. B." last="Lackey">C. B. Lackey</name></country><country name="France"><region name="Pays de la Loire"><name sortKey="Jouad, E M" sort="Jouad, E M" uniqKey="Jouad E" first="E. M." last="Jouad">E. M. Jouad</name></region><name sortKey="Bouet, G M" sort="Bouet, G M" uniqKey="Bouet G" first="G. M." last="Bouet">G. M. Bouet</name><name sortKey="Djebbar Sid, S" sort="Djebbar Sid, S" uniqKey="Djebbar Sid S" first="S." last="Djebbar-Sid">S. Djebbar-Sid</name><name sortKey="Khan, M" sort="Khan, M" uniqKey="Khan M" first="M." last="Khan">M. Khan</name><name sortKey="Thanh, X D" sort="Thanh, X D" uniqKey="Thanh X" first="X. D." last="Thanh">X. D. Thanh</name></country><country name="Algérie"><region name="Wilaya d'Alger"><name sortKey="Benali Baitich, O" sort="Benali Baitich, O" uniqKey="Benali Baitich O" first="O." last="Benali-Baitich">O. Benali-Baitich</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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